Journal: EClinicalMedicine

Article Title: A population-based analysis of the longevity of SARS-CoV-2 antibody seropositivity in the United States

doi: 10.1016/j.eclinm.2021.100902

Figure Lengend Snippet: Population IgG and Follow-up PCR Positivity Rates using LOWESS moving regression. Actual population-based IgG seropositivity (green) of both nucleocapsid ( N ) and spike ( S ) proteins together, and follow-up PCR positivity rate (red) over days from initial positive PCR test for COVID-19 are shown from index of day 0 to 300 days. Alternatively, actual daily index value (dotted line) with LOWESS moving average regression (solid line) are both shown. The 14-day post index (orange) highlights breaks in trends (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).

Article Snippet: While seropositivity rates look similar for males and females in the LOWESS smoothing curve, females do appear to have a higher seropositivity rate longer than males and our results detect these statistically significant factors that warrant further research (of note, the Labcorp® registry identified more females receiving both PCR and antibody testing, which might be attributable to prevalence of testing ordered by OB/GYN providers).

Techniques:

Journal: EClinicalMedicine

Article Title: A population-based analysis of the longevity of SARS-CoV-2 antibody seropositivity in the United States

doi: 10.1016/j.eclinm.2021.100902

Figure Lengend Snippet: Population-based seropositivity rates of Nucleocapsid ( N ) and Spike ( S ) protein IgG Assays. Seropositivity rates of IgG antibodies to Nucleocapsid (blue) and Spike (orange) proteins days following initial positive PCR test, found in the lower plot. Linear regression equation is displayed for both antibodies in the lower right corner, which starts at 21 days post positive PCR. 95% CI is represented by the shaded region above and below each linear line. The upper plot contains a frequency count of tests run (with kernel density plot) per day from index (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).

Article Snippet: While seropositivity rates look similar for males and females in the LOWESS smoothing curve, females do appear to have a higher seropositivity rate longer than males and our results detect these statistically significant factors that warrant further research (of note, the Labcorp® registry identified more females receiving both PCR and antibody testing, which might be attributable to prevalence of testing ordered by OB/GYN providers).

Techniques:

Journal: EClinicalMedicine

Article Title: A population-based analysis of the longevity of SARS-CoV-2 antibody seropositivity in the United States

doi: 10.1016/j.eclinm.2021.100902

Figure Lengend Snippet: Comparison of antibody seropositivity over time by protein type and assay platform. Seropositivity rates of IgG antibodies to Spike ( A and B ) and Nucleocapsid ( C and D ) proteins by two separate assay platforms each over days post first positive PCR result for COVID-19. Data is smoothed using LOWESS and fitted with 95% confidence intervals for variance in sample sizes. Comparison between assay platform within protein types show similarities for Spike, but different trends for Nucleocapsid.

Article Snippet: While seropositivity rates look similar for males and females in the LOWESS smoothing curve, females do appear to have a higher seropositivity rate longer than males and our results detect these statistically significant factors that warrant further research (of note, the Labcorp® registry identified more females receiving both PCR and antibody testing, which might be attributable to prevalence of testing ordered by OB/GYN providers).

Techniques: Comparison

Journal: EClinicalMedicine

Article Title: A population-based analysis of the longevity of SARS-CoV-2 antibody seropositivity in the United States

doi: 10.1016/j.eclinm.2021.100902

Figure Lengend Snippet: IgG Seropositivity Logistic Regression Variable Significance.

Article Snippet: While seropositivity rates look similar for males and females in the LOWESS smoothing curve, females do appear to have a higher seropositivity rate longer than males and our results detect these statistically significant factors that warrant further research (of note, the Labcorp® registry identified more females receiving both PCR and antibody testing, which might be attributable to prevalence of testing ordered by OB/GYN providers).

Techniques:

Journal: EClinicalMedicine

Article Title: A population-based analysis of the longevity of SARS-CoV-2 antibody seropositivity in the United States

doi: 10.1016/j.eclinm.2021.100902

Figure Lengend Snippet: Population Nucleocapsid and Spike IgG seropositivity by Demographics. Nucleocapsid and spike IgG seropositivity rates after first positive PCR test for SARS-CoV-2 using LOWESS moving average for curve smoothing. (A) Rates by gender shown with S IgG following the same trend for males (blue) and females (green), (B) Rates by age, classified as <65 (black) or ≥65 years old (gold) (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).

Article Snippet: While seropositivity rates look similar for males and females in the LOWESS smoothing curve, females do appear to have a higher seropositivity rate longer than males and our results detect these statistically significant factors that warrant further research (of note, the Labcorp® registry identified more females receiving both PCR and antibody testing, which might be attributable to prevalence of testing ordered by OB/GYN providers).

Techniques:

Journal: Thoracic Cancer

Article Title: Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer

doi: 10.1111/1759-7714.13056

Figure Lengend Snippet: Co‐plot of odds ratios (ORs, upper row) and Locally Weighted Scatterplot Smoothing curves of stage migration and determination of structural break points with the use of the Chow test (bottom row). The fitting bandwidth was 0.6. Each dot in the co‐plot represents an OR of a specific lymph node examined (LNE, vacant if case number < 10) from logistic regression analysis. ( a ) Overall patients, ( b ) adenocarcinoma patients, and ( c ) esophageal squamous cell carcinoma (ESCC) patients from the Surveillance, Epidemiology, and End Results (SEER) database; and ( d ) ESCC patients from the Thoracic Surgery Department of a single institution (SI). ( ) T1, ( ) T2, ( ) T3, and ( ) T4.

Article Snippet: **Curves were generated using odds ratios (ORs, each LNE count compared to 1 LNE as a reference) in logistic regression analysis and hazard ratios (HRs) in Cox regression analysis using Locally Weighted Scatterplot Smoothing (LOWESS, Stata 12.0) with a bandwidth of 0.6.

Techniques: Migration

Journal: Thoracic Cancer

Article Title: Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer

doi: 10.1111/1759-7714.13056

Figure Lengend Snippet: Co‐plot of hazard ratios (HRs, upper row) and Locally Weighted Scatterplot Smoothing curves of cancer‐specific survival (CSS) and determination of structural break points with use of the Chow test (bottom row). The fitting bandwidth was 0.6. Each dot in the co‐plot represents an HR of a specific lymph node examined (LNE, vacant if case number < 10) from Cox regression analysis. ( a ) Overall patients, ( b ) adenocarcinoma patients, and ( c ) esophageal squamous cell carcinoma (ESCC) patients from the Surveillance, Epidemiology, and End Results (SEER) database. ( ) T1, ( ) T2, ( ) T3, and ( ) T4.

Article Snippet: **Curves were generated using odds ratios (ORs, each LNE count compared to 1 LNE as a reference) in logistic regression analysis and hazard ratios (HRs) in Cox regression analysis using Locally Weighted Scatterplot Smoothing (LOWESS, Stata 12.0) with a bandwidth of 0.6.

Techniques:

Journal: Thoracic Cancer

Article Title: Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer

doi: 10.1111/1759-7714.13056

Figure Lengend Snippet: Co‐plot of hazard ratios (HRs, upper row) and Locally Weighted Scatterplot Smoothing curves of cancer‐specific survival (CSS) and determination of structural break points with the use of the Chow test (bottom row). The fitting bandwidth was 0.6. Each dot in the co‐plot represents an HR of a specific lymph node examined (LNE, vacant if case number < 10) from Cox regression analysis. ( a ) Node‐negative (N negative) and ( b ) node‐positive (N positive) patients. ( ) T1, ( ) T2, ( ) T3, and ( ) T4.

Article Snippet: **Curves were generated using odds ratios (ORs, each LNE count compared to 1 LNE as a reference) in logistic regression analysis and hazard ratios (HRs) in Cox regression analysis using Locally Weighted Scatterplot Smoothing (LOWESS, Stata 12.0) with a bandwidth of 0.6.

Techniques: